According to the American Diabetes Association, 1.5 million people are diagnosed with diabetes each year in the United States. Cell lines such as Beta-TC-6 can serve as transfection hosts to study diabetes and develop new treatment approaches. An optimized Beta-TC-6 transfection reagent is commercially available from Altogen Biosystems. The Beta-TC-6 cell line was derived from the pancreatic cells of a transgenic mouse with insulinoma. Beta-TC-6 cells are beta cells that exhibit an epithelial-like morphology and adherent culture properties. Beta-TC-6 cells are transgenic for SV40 large T antigen. The Beta-TC-6 cell line expresses large amounts of insulin, as well as smaller amounts of glucagon and somatostatin, in response to glucose.
Altogen Labs is a recognized developer and laboratory for genetic research. Custom research offers and additional experiments include xenografts, toxicology assays, 28-day generation of stably-transfected cells, RNAi testing and more. Dedicated to assisting pharmaceutical companies with cutting-edge and specialized services, Altogen Biosystems endeavors to optimize modern laboratory discoveries. Visit the Altogen Labs website for a comprehensive list of xenograft models and other products.
There are many pancreatic diseases that are currently being studied along with potential therapies and drugs, with diabetes and pancreatic cancer being some of the more prominent maladies. Beta-TC-6 cells, derived from transgenic mice whose pancreatic cells secreted large amounts insulin, are nonetheless cells meant for strategies to combat insulinoma, a rare type of cancer that has so far been difficult to research and find drugs against. The cells are good targets for transfection experiments and novel gene therapies that seek to alter the genome, with results informing preclinical trials and potentially leading to IND status. With quality transfection reagents, researchers can expect reliable results that can translate into human tissues.
The Beta-TC-6 cell line was derived from beta cells of a transgenic mouse suffering from insulinoma (pancreatic tumor). These cells are used in research due to their ability to synthesize glucagon, insulin, and somatostatin. Altogen biosystems transfection reagents for this cell line are highly efficient (91%) and optimized for delivery of miRNA, siRNA, mRNA and plasmid DNA.
Beta-TC-6 Transfection Reagent (Ovary Cells, CRL11506)
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